Isaac Newton uvua muledibue mu tshimenga tshia Woolsthorpe mu Angleterre, ne uvua mulonge tulasa tua Trinity College mu Iniversite wa Cambridge, kuvuaye mujikije mu tshidimu tshia 1665. Mu tshikondo tshia tshipupu tshia mu 1666, wakashala mu Woolsthorpe, mu tshikondo atshi wakalongolola dilongesha diende dia dilondangana dia malu (calcul infinitésimal) ne malu manene a dilongesha diende dia mekanike, dia malu a mitoto ne a bintu bidi bimueneka, kusangisha ne dilongesha dia bukole budi bukoka bintu pa buloba bujima. Bipeta bivuaye mupete mu makebulula ende biakafika anu mu 1669, kadi pakapinganaye mu Trinity mu 1667, wakapeta mukanda wa Bible wa Nkudimuinu wa bulongolodi bupiabupia.